Moses and Aaron did just as the LORD had commanded. He raised his staff in the presence of Pharaoh and his officials and struck the water of the Nile, and all the water was changed into blood. The fish in the Nile died, and the river smelled so bad that the Egyptians could not drink its water. Blood was everywhere in Egypt. Exodus 7:20-21
Some would like to say that a toxin entered the Nile, a sort of red tide that once struck Florida, turning the water red and killing all the sea life. The toxic water caused the frogs to go crazy, invading the landscape. When the frogs died, gnats and flies feasted off their carcasses, spreading disease to the livestock and people. Then, when the hail struck, it killed the vegetation, stirring up the locusts, filling the sky and bringing darkness to the land.
If God used natural events to cause supernatural devastation, we could still ascribe his power to his ability to predict, direct and understand those events.
While that natural domino effect may make sense, it takes away some of God’s power. It turns God into little more than a weather man, predicting forecasts but always getting it right.
While the natural explanation works for six plagues, it does not explain the transition from boils to hail, nor the transition from darkness to the death of the firstborn. It also does not explain the abundance of frogs, gnats, flies and locusts. The swarms of each were epic and highly unusual.
Remember, God introduced his power by turning a staff into a snake. There was no illusion that occurred. The staff literally turned into a snake. You can’t find a natural explanation for that.